49 Results for "

Aristolochia debilis Siebold & Zucc.

" in MedChemExpress (MCE) Product Catalog:
Products (49)

49 Results for "Aristolochia debilis Siebold & Zucc." in MCE Product Catalog:

10
Aristolochic acid A
Aristolochic acid A
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10 Publications Verification
Cat. No.: HY-N0510
CAS No.: 313-67-7
Synonyms: Aristolochic acid I; TR 1736
Category:  

Alkaloids other families Aristolochia debilis Sieb. et Zucc. Other Alkaloids Plants Disease Research Fields Aristolochiaceae Cancer

Target:  

NF-κB

Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines .
10
Aristolochic acid A sodium
Aristolochic acid A sodium
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10 Publications Verification
Cat. No.: HY-N0510A
CAS No.: 10190-99-5
Synonyms: Aristolochic acid I sodium; TR 1736 sodium
Aristolochic acid A (Aristolochic acid I) sodium is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A sodium significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A sodium reduces BLCAP gene expression in human cell lines .
6
Toosendanin
Toosendanin
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6 Cited Publications
Cat. No.: HY-N0263
CAS No.: 58812-37-6
Category:  

Triterpenes Terpenoids Melia toosendan Sieb. et Zucc. Plants Disease Research Fields Inflammation/Immunology Meliaceae

Target:  

Others

Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities .
6
Cornuside
Cornuside
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6 Cited Publications
Cat. No.: HY-N0631
CAS No.: 131189-57-6
Category:  

Cornaceae Iridoids Cornus officinalis Sieb. et Zucc. Terpenoids Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

p38 MAPK NF-κB JNK Cholinesterase (ChE) Acyltransferase NO Synthase Interleukin Related TNF Receptor Prostaglandin Receptor ERK COX

Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC50 = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, TNF-α, IL-6, and IL-1β, by suppressing NF-κB activation .
1
Aristolactam I
Aristolactam I
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1 Cited Publications
Cat. No.: HY-N2013
CAS No.: 13395-02-3
Synonyms: Aristololactam; Aristolactam
Category:  

Natural Products other families Plants Disease Research Fields Inflammation/Immunology

Target:  

Drug Metabolite Aquaporin Cadherin TGF-beta/Smad

Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis .
1
β,β-Dimethylacrylshikonin
β,β-Dimethylacrylshikonin
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1 Cited Publications
Cat. No.: HY-N5112B
CAS No.: 24502-79-2
Synonyms: Isoarnebin I
Category:  

Quinones Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Disease Research Fields Boraginaceae Naphthalene Quinones Cancer

Target:  

HIF/HIF Prolyl-Hydroxylase Apoptosis Notch NO Synthase Bcl-2 Family

β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative that can be isolated from Lithospermum erythrorhizon Sieb. et Zucc. β,β-Dimethylacrylshikonin promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. β,β-Dimethylacrylshikonin inhibits Notch-1 activation. β,β-Dimethylacrylshikonin inhibtis tumor cell proliferation, induces tumor cell apoptosis, and inhibits tumor growth .
1
Emodin-1-O-β-D-glucopyranoside
Emodin-1-O-β-D-glucopyranoside
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1 Cited Publications
Cat. No.: HY-N2394
CAS No.: 38840-23-2
Category:  

Quinones Rheum palmatum L. Polygonaceae Anthraquinones Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Bacterial

Emodin-1-O-β-D-glucopyranoside, isolated from medicinal plant Polygonum cuspidatum Sieb. & Zucc, is a potent and noncompetitive bacterial neuraminidase (BNA) inhibitor with an IC50 of 0.85 μM .
(E/Z)-Polydatin
(E/Z)-Polydatin
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Cat. No.: HY-N0120
CAS No.: 65914-17-2
Synonyms: (E/Z)-Piceid
Category:  

Stilbenes Polygonaceae Reynoutria japonica Houtt. Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Drug Isomer

(E/Z)-Polydatin ((E/Z)-Piceid) is a mixture of the E/Z configurations of Polydatin (HY-N0120A). Polydatin can be isolated from Polygonum cuspidatum, grapes, peanuts, red wine, hop pellets, cocoa-containing products and chocolate products. Polydatin exhibits multiple biological properties, such as anti-platelet aggregation, anti-low-density lipoprotein oxidation, cardioprotective activity, anti-inflammatory and immunomodulatory functions. Polydatin shows favorable cytotoxic effects against various tumor cell lines, including cervical cancer cells, liver cancer cells, and nasopharyngeal carcinoma cells .
Spathulenol
Spathulenol
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Cat. No.: HY-N1205
CAS No.: 6750-60-3
Category:  

other families Terpenoids Sesquiterpenes Plants Aristolochia yunnanensis Disease Research Fields Aristolochiaceae Cancer

Target:  

Others

Spathulenol is isolated from Aristolochia yunnanensis, and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC50 of 85.60 μg/mL in the DPPH system [1].
Aristolochic acid D
Aristolochic acid D
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Cat. No.: HY-N1465
CAS No.: 17413-38-6
Synonyms: Aristolochic acid-IVa
Category:  

other families Monophenols Ketones, Aldehydes, Acids Phenols Plants Disease Research Fields Cancer

Target:  

Phosphodiesterase (PDE) CDK Interleukin Related

Aristolochic acid D (Aristolochic acid-IVa) is an orally active PDE2 (IC50: 4.673 μM) and CDK2 (IC50: 25 μM) inhibitor that can be isolated from Aristolochia indica L. Aristolochic acid D exhibits anti-inflammatory activity and is non-carcinogenic and non-nephrotoxic. Aristolochic acid D can be used in the research of inflammation and tumor-related diseases .
Aristolone
Aristolone
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Cat. No.: HY-N1464A
CAS No.: 25274-27-5
Category:  

other families Terpenoids Sesquiterpenes Plants Disease Research Fields Cancer

Target:  

Complement System Apoptosis

Aristolone is a sesquiterpene that can be isolated from Aristolochia debilis, Rosmarinus officinalis and Ficus Auriculata. Aristolone in Ara Fruit can be used as a prediction of apoptosis in HeLa cells. Aristolone inhibits the C1 complement component. Aristolone produces cytotoxicity effects on cells. Aristolone has anticancer properties and can be studied in research for cervical cancer .
10-Deacetyltaxol
10-Deacetyltaxol
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Cat. No.: HY-N1391
CAS No.: 78432-77-6
Synonyms: 10-Deacetylpaclitaxel
Category:  

Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus wallichiana Zucc.

Target:  

Microtubule/Tubulin

10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .
Vitisin A
Vitisin A
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Cat. No.: HY-142026
CAS No.: 142449-89-6
Synonyms: (+)-Vitisin A
Category:  

Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae

Target:  

Caspase ERK NF-κB Influenza Virus PAK LDLR PPAR PCSK9 Androgen Receptor Keap1-Nrf2 Monoamine Oxidase Cholinesterase (ChE) IKK Wnt β-catenin Reactive Oxygen Species (ROS) Apoptosis Cuproptosis

Vitisin A ((+)-Vitisin A) is an orally active natural product with multiple pharmacological activities including anti-inflammatory, anti-tumor, anti-oxidant, anti-pathogenic microorganism, hypoglycemic and lipid-regulating, anti-osteoporotic, neuroprotective and cardiovascular protective effects. Vitisin A exhibits inhibitory effects on human AChE and MAO-B with IC50 values of 1.29 µM and 4.94 µM, respectively. Vitisin A inhibits the ERK, MAPK, NF-κB, STAT1, HMGCR and TRAF6 pathways, downregulates the related phosphorylation and protein expression, while activates the Nrf2/HO-1 pathway and upregulates p21 expression. Vitisin A induces tumor cell apoptosis and cell cycle arrest, inhibits adipogenesis and lipid accumulation, while alleviates oxidative stress, suppresses inflammatory responses, blocks hepatic fibrosis, Cuproptosis and cholesterol synthesis, and increases the expression levels of central BDNF and TrkB. Vitisin A can be used in the research of tumors, infectious diseases, metabolic diseases, bone and joint diseases, liver diseases, skin injuries, as well as neurodegenerative and cognitive dysfunction-related diseases .
Cirsimarin
Cirsimarin
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Cat. No.: HY-N7272
CAS No.: 13020-19-4
Category:  

Flavonoids Monophenols Leguminosae Flavones Metabolic Disease Phenols Abrus precatorius Linn. Plants Disease Research Fields

Target:  

Phosphodiesterase (PDE)

Cirsimarin is a potent antilipogenic flavonoid isolated from Microtea debilis. Cirsimarin exerts potent antilipogenic effect and decreases adipose tissue deposition in mice. The lipolytic activity of Cirsimarin resulting from both its antagonist activity on adenosin A1 receptor and its inhibitory effect on phosphodiesterase .
Guaiacin
Guaiacin
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Cat. No.: HY-N2247
CAS No.: 36531-08-5
Category:  

Zingiber officinale Roscoe Lignans Metabolic Disease Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Zingiberaceae

Target:  

Phosphatase

Guaiacin is a arylnaphthalene type lignin isolated from the barks of Machilus thunbergii SIEB. et ZUCC (Lauraceae). Guaiacin significantly increases alkaline phosphatase activity and osteoblast differentiation .
Aristolochic acid III
Aristolochic acid III
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Cat. No.: HY-N7951
CAS No.: 7267-92-7
Category:  

Aristolochia debilis Sieb. et Zucc. Ketones, Aldehydes, Acids Plants Aristolochiaceae

Target:  

Others

Aristolochic acid III is a natural product that can be isolated from the leaves of Aristolochia debilis .
7-Hydroxyaristolochic acid A
7-Hydroxyaristolochic acid A
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Cat. No.: HY-N2012
CAS No.: 79185-75-4
Category:  

Monophenols Ketones, Aldehydes, Acids Aristolochia Phenols Plants Disease Research Fields Inflammation/Immunology Aristolochiaceae

Target:  

Others

7-Hydroxyaristolochic acid A is an aristolochic acid analogue found in Aristolochia plants. Aristolochic acid can be used as an anti-inflammatory agent .
Aristolactam A II
Aristolactam A II
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Cat. No.: HY-N2891
CAS No.: 53948-07-5
Synonyms: Aristololactam A II
Category:  

Piper longum Linn. Alkaloids Pyrrole Alkaloids Piperaceae Plants

Target:  

Parasite COX

Aristolactam A II (Aristololactam A II) is a weak COX inhibitor with cytotoxic and anti-plasmodial activities. Aristolactam A II exhibits inhibitory activity against Chloroquine (HY-17589A)-sensitive strains, and exerts its inhibitory effect on Plasmodium falciparum growth by inducing cell membrane damage marked by LDH release. Aristolactam A II can be applied to the research of malaria-related mechanisms .
7-(2'-Deoxyadenosin-N6-yl)aristolactam I
7-(2'-Deoxyadenosin-N6-yl)aristolactam I
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Cat. No.: HY-N8292
CAS No.: 127191-86-0
Category:  

Alkaloids Aristolochia debilis Siebold & Zucc. Other Alkaloids Plants Aristolochiaceae

Target:  

Others

7-(2'-Deoxyadenosin-N6-yl)aristolactam I is a Alkaloids product that can be isolated from the herbs of Aristolochia debilis Sieb. et Zucc .
β-Sitosterol acetate, 95%
β-Sitosterol acetate, 95%
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Cat. No.: HY-W127616A
CAS No.: 915-05-9
Synonyms: Sitosteryl acetate, 95%
β-Sitosterol acetate, 95% (Sitosteryl acetate, 95%) is a sterol that can be isolated from Hechtia glomerata Zucc., which has antibacterial activity and has a MIC value of 100µg/mL against carbapenem-resistant Acinetobacter baumannii .
Assay Types